Before and After Results, Dosage, Side Effects

Ostarine is a second-generation selective androgen receptor modulator (SARM), additionally known as Enobosarm or MK-2866.

The goal with the formulation of ostarine and different SARMs is to imitate the anabolic results of steroids with out the cruel unwanted effects. This doubtlessly will guarantee a safer and extra efficacious remedy for sufferers affected by cachexia, osteoporosis, and anemia.

GTx, Inc., a US biotechnology agency, first described and developed MK-2866 in 2001. Since then, part 1, 2, and 3 medical trials have evaluated it.

In part 3 trials, GTx introduced that ostarine was unsuccessful within the remedy of breast most cancers sufferers affected by cachexia. This was resulting from insignificant enhancements in muscular power, regardless of will increase in muscle hypertrophy.

This has led GTx to stop its pursuit of ostarine for the remedy of cachexia. However, the biotechnology firm stays dedicated to modifying MK-2866 for improved success sooner or later.

Is Ostarine FDA-Approved?

Given its latest creation, the FDA has not authorized ostarine for human use. Consequently, sporting organizations reminiscent of WADA prohibit its acquisition for beauty functions. It can be unlawful to make use of ostarine for beauty functions, with solely scientific analysis permitted. This has led to SARM producers modifying their advertising and marketing technique, labeling merchandise as analysis chemical compounds as a substitute of dietary dietary supplements, successfully capitalizing on this chance.

Travis Tygart, CEO of USADA, has acknowledged that he’s “legislative choices” to take away ostarine and different SARMs from the market.

What Are the Benefits of Ostarine?

Muscle Size and Strength

Ostarine works like anabolic steroids by activating the androgen receptor, growing bone and muscle power. Ostarine additionally enhances satellite tv for pc cell cycle activation, ensuing within the fusing of myofibers and growing myonuclei within the muscle mass.

Because ostarine solely impacts sure tissues, it may well construct lean muscle with out the androgenic unwanted effects of anabolic steroids. This prevents benign prostatic hyperplasia (BPH) from occurring.

• In one examine on aged males and ladies, contributors elevated their lean physique mass by 3% after consuming 3 mg/day of ostarine for 12 weeks (1).
• This is the equal of an 80 kg (176 lb) man buying 2.4 kg (5.3 lb) of muscle.

Given that the prescribed dosage of three mg/day is simply a fraction of the dose weightlifters usually administer to enhance their physique composition, these outcomes are encouraging. The aged males and ladies additionally skilled important will increase in muscular power, including 22 lb to their bench press by the twelfth week.

No Virilization in Women

Women are significantly susceptible to virilization results when taking steroidal compounds. Nonetheless, we’ve decided that ostarine is secure on this context. Elderly ladies within the above-cited examine additionally skilled no masculinization results.

Fat Loss

Ostarine is an efficacious SARM for chopping as a result of it may well improve insulin sensitivity, which results in subcutaneous and visceral fats loss.

The discount of visceral fats is a singular attribute of ostarine, in distinction to numerous anabolic steroids, which may improve visceral fats. This elucidates why some steroid customers develop a distended waistline, a sign of elevated visceral fats ranges. Nevertheless, ostarine customers will expertise fats loss all through the physique, significantly within the midsection, decreasing total waist circumference.

Ostarine additionally possesses optimistic metabolic results, growing calorie expenditure and satiety. Thus, it has direct and oblique lipolytic results.

In the aged examine, customers skilled a 0.6 kg (1.3 lb) discount in fats mass. However, we’ve noticed further fats loss in non-elderly customers on ostarine when combining it with normal weightlifting and cardiovascular train. Thus, being sedentary could inhibit fats loss on ostarine.

Disclosure: We don’t allow any type of promoting on Inside Bodybuilding. We monetize our follow by physician consultations and meticulously chosen complement suggestions, which have yielded distinctive outcomes in our sufferers. 

Best SARMs Company in 2025

What Are the Side Effects of Ostarine?

Dr. Mike Israetel says that SARMs typically have “comparable unwanted effects” to anabolic-androgenic steroids. However, he provides that some SARMs, reminiscent of ostarine, could also be “secure” and “efficient.”

Ostarine doesn’t seem to trigger hypertrophy of the prostate; nonetheless, it does reproduce a number of anabolic steroid unwanted effects.

Testosterone Suppression

The males within the cited aged examine who took 3 g/day of ostarine for 12 weeks skilled minimal fluctuations of their serum testosterone ranges. Some of our sufferers using extra substantial dosages of ostarine have reported normal libido, nocturnal erections, and testicular quantity when taking 25 mg/day for six weeks.

However, our SHBG checks point out that ostarine may cause low testosterone ranges post-cycle. One person scored 148 ng/dL, in comparison with a median rating of 264-916 ng/dL for his age vary. This occurred after taking 20 mg/day of ostarine for a interval of 8 weeks.

Thus, primarily based on current analysis and our anecdotal proof, it’s affordable to conclude that ostarine has no important impact on endogenous testosterone ranges when taken in conservative dosages.

However, in elevated dosages, ostarine displays a suppressant impact, which can not invariably end in perceivable unwanted effects.

Ostarine is a light SARM; due to this fact, full shutdown of the hypothalamic-pituitary-testicular axis (HPTA) is unlikely. Dr. Nicholas Downey states that in rodents, luteinizing hormone and follicle-stimulating hormone ranges stay largely “unaffected” by ostarine. However, he provides that prolactin “could also be a problem” in delicate customers using ostarine, resulting from it being a weak antagonist of the progesterone receptor.

Liver Toxicity

In the aged examine, AST and ALT liver markers elevated above normal ranges in 20% of contributors, indicating ostarine’s hepatotoxic potential. Although AST and ALT ranges didn’t rise to a harmful stage, these contributors solely acquired a fraction of the dose in comparison with those that use ostarine for physique-enhancing functions.

The oral administration of ostarine, which should bypass the liver earlier than changing into absolutely energetic, contributes to its hepatotoxicity.

We have discovered that different SARMs, reminiscent of LGD-4033 and RAD-140, even have the potential to trigger hepatocellular-cholestatic liver harm (2).

Cholesterol Issues

Taking 3 mg/day of ostarine for 12 weeks led to a 27% discount in HDL ldl cholesterol, which is useful for cardiovascular well being. This examine’s diminutive dosage raises considerations about such reductions.

Thus, ostarine has the potential to extend myocardial infarction threat within the brief or long run, even in modest doses.

The oral nature of ostarine and different SARMs could contribute to their antagonistic results on HDL and LDL levels of cholesterol. This is because of them stimulating hepatic lipase within the liver upon entry, an enzyme identified for reducing HDL and growing arterial plaque.

Gynecomastia and Water Retention

Several SARMs can elevate estrogen not directly through binding to the androgen receptor. This leaves further testosterone free and accessible to transform to estrogen.

Consequently, a few of our sufferers have reported experiencing bloating or gynecomastia when utilizing SARMs, regardless that the aromatase enzyme will not be current. However, on ostarine, we generally observe a dry look within the muscle mass with minimal extracellular fluid.

Furthermore, improved insulin sensitivity on ostarine additionally signifies its minimal impact on estrogen, thereby decreasing the chance of growing gynecomastia.

One of our sufferers lately had his estradiol ranges examined post-ostarine. They recorded 17.4 pg/mL and thus had been inside a traditional vary. The common estradiol vary is 7.6-42.6 pg/mL.

Hair Loss

Just a few of our sufferers have reported hair loss or recession throughout an ostarine cycle, regardless of the 5-alpha reductase enzyme failing to be current.

The wrongdoer behind androgenetic alopecia is elevated dihydrotestosterone (DHT) ranges. Increases in DHT happen not directly as ostarine competes with customers’ pure testosterone when binding to the androgen receptor. In this occasion, ostarine is the stronger substance, thus leaving surplus free testosterone to transform to DHT. Although incidents of hair loss on ostarine are rare in comparison with anabolic steroids, androgenetic alopecia stays attainable.

Ostarine Before and After 45 Days

• The Reddit person’s outcomes had been achieved by taking 20 mg/day of ostarine for 45 days, mixed with typical weight coaching strategies.
• The person misplaced 3 kg (7 lb) but seems more and more muscular. This is because of enhanced muscle definition reasonably than elevated hypertrophy.

Therefore, the scales could not precisely mirror outcomes when taking ostarine as a result of simultaneous results of muscle-building and fats loss. Before and after footage are due to this fact essential when monitoring progress pre- and post-cycle.

Note: In our expertise, this person’s outcomes are above common. Coincidentally, he was coaching extra often on ostarine, thus contributing to a portion of the muscle tissue and fats loss.

Ostarine Before and After 5 Weeks

• This Reddit person misplaced 13 lb after biking ostarine for six weeks. He administered 12.5 mg/day throughout week 1 and 25 mg/day for the remaining 5 weeks.
• He reported no unwanted effects, at the very least to his information, however skilled a notable quantity of fats loss, accompanied by will increase in muscle fullness and vascularity.

Note: Eating in a calorie deficit could have contributed to a portion of the fats loss he skilled throughout his transformation.

He believes ostarine didn’t assist him in accumulating muscle mass however seemingly contributed to muscle retention throughout his cycle. His power ranges remained steady all through his 6-week cycle.

Ostarine Before and After 8 Weeks

• This Reddit person misplaced 23 lb after administering 20 mg/day for 8 weeks.
• He adopted a calorie-deficit food regimen throughout his cycle, contributing to substantial fats loss. He doesn’t seem to have added any marked muscle mass, regardless of huge enhancements in muscle definition.

He reported no enhancements in power. However, he credit ostarine for preserving muscle hypertrophy and power whereas consuming low energy, particularly 1,800 energy/day.

In phrases of unwanted effects, he monitored his liver enzymes and testosterone post-cycle. His ALT liver enzyme rating was excessive, at 57 IU/L. This is roughly 30% increased than most common ranges.

He additionally transitioned to a hypogonadal state and was eligible for prescribed testosterone alternative remedy. He reported physiological and psychological decline post-cycle: feeling jaded and experiencing diminished well-being. This is regardless of the person not reporting “a excessive” all through the ostarine cycle.

We have discovered ostarine’s outcomes to be akin to a light Anavar or Winstrol cycle, with muscle hypertrophy and fats loss occurring synergistically. These three compounds additionally share comparable unwanted effects.

Ostarine Dosage

Ostarine doesn’t have established dosage tips resulting from a scarcity of FDA approval. However, medical research have efficiently administered doses of three mg, 9 mg, and 18 mg/day.

• Those taking ostarine to boost their physique composition generally take 10–30 mg/day.
• Women usually take the decrease worth of this vary, reminiscent of 10 mg/day, in a bid to keep away from virilization results.

Higher dosages of ostarine are believed to additional promote muscle hypertrophy, making them efficacious throughout a lean bulking cycle. Lower dosages primarily improve fats loss, making them extra applicable for chopping cycles.

We have noticed increased ostarine dosages to exacerbate unwanted effects, together with:

1. Cholesterol values
2. Liver values
3. Testosterone suppression

Ostarine Cycle

This is a standard ostarine-only cycle we’ve seen utilized by sufferers for fats loss and muscle retention.

• They administered 20 mg/day of ostarine sublingually for 8 weeks.

Note: Men generally execute the cycle above. Women usually administer 10 mg/day for 4–8 weeks.

Individuals can cycle ostarine for as much as 12 weeks in some instances. However, that is solely felicitous if ldl cholesterol, liver, and testosterone values haven’t excessively deteriorated from the primary 8 weeks.

Ostarine will be cycled with different SARMs concurrently; nonetheless, this isn’t suggested resulting from additional elevations of blood strain and liver enzymes.

Ostarine and Cardarine Cycle

• Ostarine: 20 mg/day for 8 weeks
• Cardarine: 20 mg/day for 8 weeks

Some customers generally stack ostarine with cardarine for extra distinguished fats loss throughout chopping cycles.

Cardarine will not be a SARM however a peroxisome proliferator-activated receptor delta (PPARD) agonist. Cardarine has a optimistic impact on insulin sensitivity and fatty acid oxidation.

Research has discovered cardarine to considerably lower adipose tissue, each in animal and human research (3).

Our lipid profiles have proven cardarine to have cardioprotective properties, growing HDL levels of cholesterol (4) and thus doubtlessly decreasing elevations in blood strain from ostarine.

However, Dr. Thomas O’Connor has noticed hepatotoxic results from cardarine primarily based on his commentary of affected person labs in over 2,000 SARM customers. He likens cardarine’s antagonistic results on the liver to taking 50 mg/day of Anavar. Thus, stacking cardarine with ostarine is prone to exacerbate liver values.

Cardarine’s latest formulation qualifies it as a analysis chemical much like SARMs.

Since cardarine first appeared in scientific analysis in 2001, its unwanted effects are nonetheless unclear.

The concern with cardarine is its carcinogenic threat (5), with long-term animal research demonstrating an indeniable correlation with its use and numerous cancers.

The health neighborhood has criticized these research for utilizing excessively excessive dosages. However, even the smallest cardarine dosage proved to be carcinogenic. This features a 5 mg/kg dose, equal to 65 mg for an 80 kg human. Men and ladies at this time use this dose for beauty functions. As a consequence, the protection of cardarine is unsure, resulting in the discontinuation of medical trials in 2009.

How to Take Ostarine?

Ostarine usually comes as an oral resolution, dosed at 25 mg/mL, and is taken by mouth.

Users can measure the dose with an eye fixed dropper or syringe earlier than putting it within the mouth.

Researchers may also administer ostarine sublingually, putting the liquid underneath the tongue for 10-15 seconds earlier than swallowing.

Such placement permits the liquid to contact and penetrate the mucous membrane, making a extra direct and expeditious entry into the bloodstream (6).

This administration methodology additionally inhibits presystemic metabolism, growing ostarine’s organic availability.

Ostarine is often accessible in capsule type, with 10 mg of ostarine usually being current in every capsule.

Ostarine Reviews

Researchers in our Facebook group have revealed the next Ostarine evaluations.

I used to be extraordinarily suppressed after 8 weeks of 20 mg of ostarine. You could not want a PCT, however all the time have your PCT readily available earlier than you begin this. I did this similar stack 8 weeks in the past, and I felt super with very optimistic outcomes.

---

Ostarine is my favourite SARM. In my private expertise, I’ve tried 10 mg/day to 50 mg/day, and I consider 25 mg is the optimum dose. I counsel getting bloodwork earlier than you begin and when you find yourself executed. I ran perhaps 8 or 9 cycles with no suppression by any means, however my final cycle shut me down utterly, and my PCT didn’t restart my balls. Consider wanting into GW-501516 or GW-0742, as Ostarine can negatively influence your ldl cholesterol ratio (however these compounds do an exceptional job serving to to control that whereas selling fats loss and vitality). Ostarine is fairly liver poisonous, so I strongly counsel 1,200 mg/day of NAC (and/or TUDCA) to mitigate the elevation in AST and ALT you’ll positively expertise.

---

I ran ostarine at 50 mg per day and felt like garbage. Worse than every other SARM. Everyone is totally different, although. I by no means actually preferred ostarine. Makes me torpid.

---

Finished a 12-week ostarine (20 mg) day by day 4 weeks in the past. I elevate weights 2 days per week and prepare Muay Thai 2-3 days per week. Happy with the outcomes, I gained about 4 kg and some good power. Ostarine appealed to me as a result of it’s delicate, has no again pumps or shoulder pumps, and I by no means felt shut down.

---

Using 15 mg a day in the intervening time, blown away by the power features and recomp results it’s had in as little as 30 days. Very easygoing on lipids too, which simply makes this my favourite SARM.

Frequently Asked Questions

Can Ostarine Cause Bloating?

Several of our sufferers have reported bloating from ostarine. For some, this ceased after a few weeks of supplementation, and for others it endured till cycle cessation. We have discovered that anti-estrogen medicines can fight water retention and bloating on ostarine and different SARMs.

Is 10 mg of Ostarine Enough?

10 mg/day is the usual dosage utilized by females. It is the decrease finish of the usual dosage for males, with 30 mg/day being the excessive finish of this vary. 10 mg/day is prone to produce fewer unwanted effects in comparison with bigger dosages, with much less pronounced anabolism and lipolysis.

What is the Price of Ostarine?

The value of ostarine can fluctuate relying on the supply. Higher-quality merchandise are prone to value extra resulting from elevated manufacturing prices and superior purity ranges. Below is a listing of present liquid ostarine costs:

• Sports Technology Labs: $54.99
• Chemyo: $69.99
• Pure Rawz: $75.95
• Behemoth Labz: $79.95

Should Ostarine Be Taken on an Empty Stomach?

Our sufferers have taken ostarine with and with out meals, and there seems to be no perceivable distinction in outcomes.

When is the Best Time to Take Ostarine?

For some customers, we’ve discovered that taking ostarine within the night can improve the danger of insomnia. Thus, we usually administer ostarine within the morning and repeat this dosing each 24 hours.

How Long Does It Take to See Results?

Results can usually be noticed visually throughout the first 2 weeks of supplementation. Fluctuations in weight will not be a dependable indicator of outcomes resulting from simultaneous muscle achieve and fats loss.

Can I Take Ostarine Pre-Workout?

Some customers administer ostarine pre-workout for elevated depth. However, if the exercise is within the night and the person is prone to poor high quality sleep, then they might not take it earlier than train. Equally, if a person generally experiences dyspepsia, in any other case often called an upset abdomen, after dosing, they might go for a distinct time.

Can Ostarine Cause Diabetes?

No, ostarine doesn’t seem to trigger diabetes in medical literature or in our expertise. Research reveals that ostarine can lower fasting blood glucose by 11% (7).

Ostarine Pros and Cons

Pros:

• Fat burning
• Muscle-building
• Strength-enhancing

Cons:

• Some poisonous results
• Not as potent as different SARMs

Ostarine, or MK-2866, displays potent fat-burning properties attributed to its optimistic results on insulin sensitivity and stimulation of the androgen receptor.

Results by way of lean muscle, nonetheless, are modest and ought to be thought-about inferior to stronger SARMs, reminiscent of LGD-4033 or RAD-140.

Individuals usually underestimate the severity of SARMs’ unwanted effects. Even delicate SARMs reminiscent of ostarine current toxicity in relation to the center and liver. Testosterone suppression can be prone to happen, negatively affecting the HPTA. Clomid can speed up the restoration of the HPTA, shortening the time span of low testosterone signs (8).

How Does Ostarine Compare to Anavar?

Anavar, an oral steroid, could pose fewer dangers than ostarine, with a number of many years of medical analysis documenting its results. However, Anavar displays comparable unwanted effects to ostarine within the following areas:

1. Cholesterol alterations
2. Raised liver enzymes
3. Testosterone suppression

Side results from Anavar in therapeutic dosages are sometimes unproblematic, therefore Anavar’s former FDA-approved standing in medication.

Thus, we discover Anavar’s risk-to-reward ratio to be extra fascinating than ostarine’s, because it yields superior outcomes by way of fats loss, power, and muscle hypertrophy.

Co Authors :

For TRT inquiries, please contact Dr. O’Connor through the Anabolic Doc app.

Over the final 20 years, Dr. O’Connor has efficiently handled 1000’s of males who’ve taken anabolic steroids, SARMs, and different PEDs, giving him first-hand expertise of their results. Board-certified MD since 2005.

You shouldn’t have any posts.